J. formation of micronuclei and multinucleation through its conversation with one of the crucial spindle checkpoint proteins, Bub1, and the producing degradation of Bub1. This conversation occurs through the Knl and CIL56 kinase domains of Bub1, identified as important for stability and degradation. These results suggest that LANA can dysregulate Bub1 activity, which leads to … Continue reading J